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Alcohol Has a Greater Adverse Effect on Women

Heart Risks Greater
for Women Drinkers

By BuddyT

Women appear to be more sensitive than men to alcohol's toxic effects on the heart.

Some female alcoholics experience more severe cardiovascular effects from heavy alcohol drinking than those observed in male alcoholics and these effects are noted at an earlier stage of drinking and at a lower consumption level than those noted in men.

Researchers at the National Center for PTSD have confirmed that some female alcoholics experience more severe cardiovascular effects from heavy alcohol drinking than those observed in male alcoholics, and these effects are noted at an earlier stage of drinking and at a lower consumption level than those noted in men.

Cardiovascular Complications Begin Earlier for Women

"This work adds to the growing body of literature that confirms what many researchers in the field have suspected," said Nancy C. Bernardy, a research psychologist. "The use of drugs, such as alcohol and nicotine, has a greater adverse impact on women than on men."

This phenomenon - where women need to drink a lesser amount of alcohol than men do, or for a shorter amount of time, to produce the same degree of damage - is referred to as "telescoping."

"Additionally," said Bernardy, also the first author of the study, "I think that this work adds to growing evidence that there are subtle differences in the cardiovascular systems of women in general compared to those of men. Women's hearts are not just smaller versions of men's. Their cardiovascular systems respond differently, and this is particularly true in response to stress and toxins like alcohol.

Woman Exposed to Greater Risk

Women need to know that they may be exposing themselves to a greater risk of heart disease than the risk noted in men by their behaviors as well as the way they handle stress."

This study looked at 32 inpatient female alcoholics, abstinent for four weeks, and 16 female social drinkers. Researchers examined the participants' blood pressure, heart rate, stroke volume and vascular resistance during rest and in response to two stress tests: a five-minute hand grip task, and a five-minute speech exercise.

The alcoholics were then divided into subgroups according to their withdrawal blood pressures: those with transitory hypertension (tHT), occasional above-normal blood pressure that normalized after withdrawal, and those with normal blood pressure throughout withdrawal and treatment.

Problems Continue After Abstinence

"The women with tHT showed dysfunction across most of the cardiovascular measures," said Candice M. Monson, assistant professor of psychiatry at Dartmouth Medical School. "The alcohol-dependent women who experienced hypertension related to detoxification also showed a protracted pattern of cardiovascular dysfunction after a period of abstinence from alcohol. This is in contrast to previous studies showing that men with tHT return to 'normal' resting cardiovascular functioning after a period of abstinence, and manifest cardiovascular dysfunction only when faced with an aversive stressor.

"Furthermore, this finding is congruent with recent studies showing that cardiovascular effects in women are more severe than in men, and emerge sooner with chronic drinking."

Irreparable Heart Damage

Both Bernardy and Monson noted that these findings suggest that a subgroup of women may compromise, perhaps irreparably, their cardiovascular systems through chronic, heavy alcohol consumption.

"The short-term implication of this dysregulation may be evidenced as an increased risk for the development of hypertension," said Bernardy, "with the long-term implication of an increased risk for the development of future cardiovascular disorders such as heart attacks, strokes, or cardiomyopathy."


Bernardy NC, et al. "Cardiovascular Responses to Physical and Psychological Stress in Female Alcoholics With Transitory Hypertension After Early Abstinence." Alcoholism: Clinical & Experimental Research DOI: 10.1097/01.ALC.0000085587.00498.38

Ceccanti M, et al. "Hypertension in early alcohol withdrawal in chronic alcoholics." Alcohol and Alcoholism 2006 Jan-Feb;41(1):5-10

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